Changes in Microbiota in Type II Diabetes Patients

Anita Skovbjerg Hjort-Gregersen - s201190
Asiya Mohamad Yusuf Muses - 243930
Magnus Harthimmer - s233426
Marco Andreis - s243116
Rebecca Hjermind Millum - s215024

2024-12-03

Humans as a complex ecosystems

  • key point 1
  • key point 2
  • key point 3

Data set history

  • 8 human associated shot-gun metagenomics studies
  • Consolidated for assessment of relative abundance
  • Converted to CSV and posted on Kaggle

Diagram of data processing

Data selection

  • Selecting the WT2D data set
  • Data processing

The WT2D dataset

Hallmarks of Diabetes

HDL (“Good Cholesterol”)

  • Lower in Type 2 Diabetes
  • Risk: Heart disease, stroke
  • Factors: Medications, overweight
  • Distribution: Shift to lower values

Hemoglobin A1C

  • Measures: Avg. glucose (10–12 weeks)
  • Threshold: >48 mmol/mol = Type 2 Diabetes
  • Findings: 34% of Type 2 Diabetes cases above threshold

BMI

  • Not Significant
  • Waist Circumference: Stronger correlation

Hallmark of Type 2 Diabetes

GAD-Antibodies

  • Associated with Type 1 Diabetes
  • Pattern consistent across BMI classes

C-Peptide

  • Marker for insulin production
  • Higher in Type 2 Diabetes

Fasting Insulin

  • Higher in Type 2 Diabetes
  • Statistically significant parameter

Hallmarks of Type II Diabetes

Analysing the abundances

Statins - How do they interact?

Does diabetes change the microbiota?

Conclusions